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Operon Browser for M. tuberculosis H37Rv (83332) • Randomly selected an operon

There are 764 total operons predicted by the MicrobesOnLine.org method for the H37Rv genome.
• The numbered grey boxes are 'segments' of the genome, each containing a visible set of operons to be displayed.
• The colored boxes below are operons. Mouse over to see some information and click them to view the operon page.

Name Rvmc3: 15,590 to 23,737  •  6 Members

More operon predictions in which 1 or more members has been predicted:
Rv0014cRvmc3MicrobesOnLine.org
Rv0014cRv_dir5The University of Maryland Center for Bioinformatics and Computational Biology
Rv0014cpknB-pppGenBank's internal operon classification
Rv0014cnar_Rv0014c-Rv0015cA predicted operon map for Mycobacterium tuberculosis. Nucleic Acids Res. 2007;35(15):5085-95. 2007 Jul 25.

Rv0015cRvmc3MicrobesOnLine.org
Rv0015cRv_dir5The University of Maryland Center for Bioinformatics and Computational Biology
Rv0015cpknB-pppGenBank's internal operon classification
Rv0015cnar_Rv0014c-Rv0015cA predicted operon map for Mycobacterium tuberculosis. Nucleic Acids Res. 2007;35(15):5085-95. 2007 Jul 25.
Rv0015cOpMeth_Rv0015cInference of protein function and protein linkages in Mycobacterium tuberculosis based on prokaryotic genome organization: a combined computational approach. Genome Biol. 2003;4(9):R59. 2003 Aug 29.

Rv0016cRvmc3MicrobesOnLine.org
Rv0016cRv_dir5The University of Maryland Center for Bioinformatics and Computational Biology
Rv0016ckyoto4_drtODB (Operon DataBase), Shujiro Okuda, Kyoto
Rv0016cpknB-pppGenBank's internal operon classification
Rv0016cnar_Rv0016c-Rv0017cA predicted operon map for Mycobacterium tuberculosis. Nucleic Acids Res. 2007;35(15):5085-95. 2007 Jul 25.
Rv0016cOpMeth_Rv0015cInference of protein function and protein linkages in Mycobacterium tuberculosis based on prokaryotic genome organization: a combined computational approach. Genome Biol. 2003;4(9):R59. 2003 Aug 29.

Rv0017cRvmc3MicrobesOnLine.org
Rv0017cRv_dir5The University of Maryland Center for Bioinformatics and Computational Biology
Rv0017ckyoto4_drtODB (Operon DataBase), Shujiro Okuda, Kyoto
Rv0017cpknB-pppGenBank's internal operon classification
Rv0017cnar_Rv0016c-Rv0017cA predicted operon map for Mycobacterium tuberculosis. Nucleic Acids Res. 2007;35(15):5085-95. 2007 Jul 25.
Rv0017cOpMeth_Rv0015cInference of protein function and protein linkages in Mycobacterium tuberculosis based on prokaryotic genome organization: a combined computational approach. Genome Biol. 2003;4(9):R59. 2003 Aug 29.

Rv0018cRvmc3MicrobesOnLine.org
Rv0018cRv_dir5The University of Maryland Center for Bioinformatics and Computational Biology
Rv0018cpknB-pppGenBank's internal operon classification
Rv0018cOpMeth_Rv0015cInference of protein function and protein linkages in Mycobacterium tuberculosis based on prokaryotic genome organization: a combined computational approach. Genome Biol. 2003;4(9):R59. 2003 Aug 29.

Rv0019cRvmc3MicrobesOnLine.org
Rv0019cRv_dir5The University of Maryland Center for Bioinformatics and Computational Biology
Rv0019cOpMeth_Rv0015cInference of protein function and protein linkages in Mycobacterium tuberculosis based on prokaryotic genome organization: a combined computational approach. Genome Biol. 2003;4(9):R59. 2003 Aug 29.



1
Rv0014c: INVOLVED IN SIGNAL TRANSDUCTION (VIAPHOSPHORYLATION). THOUGHT TO REGULATE CELLDIVISION/DIFFERENTIATION. CAN PHOSPHORYLATE THE PEPTIDESUBSTRATE MYELIN BASIC PROTEIN (MBP) [CATALYTIC ACTIVITY:ATP + A PROTEIN = ADP + A PHOSPHOPROTEIN].
Rv0014c, (MTCY10H4.14c), len: 626 aa. pknB,transmembrane serine/threonine-protein kinase (EC 2.7.1.-)(see citations below), equivalent to MLCB1770_9|T10009probable serine/threonine-specific protein kinase fromMycobacterium leprae (622 aa), FASTA scores: opt: 3600,E(): 0, (86.4% identity in 626 aa overlap). Also similar(highly similar in N-terminus) to others e.g. T36717 fromStreptomyces coelicolor (673 aa); NP_389459.1|NC_000964from Bacillus subtilis (648 aa); NP_465345.1|NC_003210from Listeria monocytogenes (655 aa); E235741 proteinkinase pknB (315 aa), FASTA scores: opt: 1839, E(): 0,(90.8 identity in 305 aa overlap); etc. Contains PS00107Protein kinases ATP-binding region signature, and PS00108Serine/Threonine protein kinases active-site signature.Contains Hank's kinase subdomain. BELONGS TO THE SER/THRFAMILY OF PROTEIN KINASES. Experimental studies showevidence of auto-phosphorylation on serine/threonineresidues.
experimental evidence, no additional detailsrecorded
External Links: 15607156P0A5S4887072

2
Rv0015c: INVOLVED IN SIGNAL TRANSDUCTION (VIAPHOSPHORYLATION). THOUGHT TO REGULATE MORPHOLOGICALCHANGES ASSOCIATED WITH CELL DIVISION/DIFFERENTIATIONPROCESS. PHOSPHORYLATES AT SERINE AND THREONINE RESIDUES[CATALYTIC ACTIVITY: ATP + A PROTEIN = ADP + APHOSPHOPROTEIN].
Rv0015c, (MTCY10H4.15c), len: 431 aa. pknA,transmembrane serine/threonine-protein kinase (EC2.7.1.-), magnesium/manganese dependent (see citationsbelow), equivalent to MLCB1770_10|NP_301143.1|NC_002677putative serine/threonine protein kinase fromMycobacterium leprae (437 aa), FASTA scores: opt: 1883,E(): 0, (72.1% identity in 434 aa overlap). And alsohighly similar to other kinases from Mycobacterium lepraee.g. MLCB1770_10 from Mycobacterium leprae (437 aa). Alsosimilar to PKNA_MYCLE protein kinase (253 aa), FASTAscores: opt: 1525, E(): 0, (95.0% identity in 242 aaoverlap); etc. Also highly similar in part to others e.g.N-terminus of NP_243370.1|NC_002570 from Bacillushalodurans (664 aa); N-terminus of T36717 fromStreptomyces coelicolor (673 aa); etc. Also similar toothers from Mycobacterium tuberculosis: MTCY10H4_15,MTV021_9, MTCY28_5, MTCY4C12_28, MTCY50_16, MTCY8D9_8,MTCY49_28, MTCY4C12_30, MTCY28_9, etc. Contains PS00108Serine/Threonine protein kinases active-site signature.Contains Hank's kinase subdomain. BELONGS TO THE SER/THRFAMILY OF PROTEIN KINASES. It has been shown that sodiumorthovanadate inhibits the activity of the enzyme invitro.
experimental evidence, no additional detailsrecorded
External Links: 15607157P65726885953

3
Rv0016c: INVOLVED IN PEPTIDOGLYCAN SYNTHESIS (AT THEFINAL STAGES). CELL WALL FORMATION; PBPA IS SUPPOSED TO BERESPONSIBLE FOR THE DETERMINATION OF THE ROD SHAPE OF THECELL. ITS SYNTHESIZES CROSS-LINKED PEPTIDOGLYCAN FROMLIPID INTERMEDIATES.
Rv0016c, (MTCY10H4.16c), len: 491 aa. ProbablepbpA, penicillin-binding protein, equivalent toNP_301144.1|NC_002677 putative penicillin-binding proteinfrom Mycobacterium leprae (492 aa); and highly similar toMLCB1770_1 penicillin binding protein from Mycobacteriumleprae (474 aa), FASTA scores: opt: 2516, E(): 0, (82.4%identity in 472 aa overlap). Also similar to others e.g.T36716 from Streptomyces coelicolor (490 aa);AAF61246.1|AF241575|PbpA from Streptomyces griseus (485aa); NP_347146.1|NC_003030 from Clostridium acetobutylicum(482 aa); E235825|pbpA penicillin binding protein (325aa), FASTA scores: opt: 1618, E(): 0, (78.3% identity in323 aa overlap); etc. And also similar to MTCY270_5 andMTV003_8 from Mycobacterium tuberculosis.
experimental evidence, no additional detailsrecorded
External Links: 15607158P71586887078

4
Rv0017c: THIS IS A SEPTUM-PEPTIDOGLYCAN BIOSYNTHETICPROTEIN, INVOLVED IN CELL WALL FORMATION. PLAYS A ROLE INTHE STABILIZATION OF THE FTSZ RING DURING CELL DIVISION.
Rv0017c, (MTCY10H4.17c), len: 469 aa. Probable rodA(alternate gene name: ftsW), cell division protein,integral membrane protein, equivalent toMLCB1770_12|T10012 probable cell division protein fromMycobacterium leprae (465 aa), FASTA scores: opt: 2475,E(): 0, (81.9% identity in 469 aa overlap). Also highlysimilar to others e.g. T36715|SCH69.16 from Streptomycescoelicolor (479 aa); NP_243432.1|NC_002570 from Bacillushalodurans (366 aa); NP_347145.1|NC_003030 fromClostridium acetobutylicum (400 aa); etc. Also similar toMTCY270_14 from Mycobacterium tuberculosis FASTA score:(32.2% identity in 369 aa overlap). BELONGS TO THEFTSW/RODA/SPOVE FAMILY.; ftsW
External Links: 15607159P63760887075

5
Rv0018c: INVOLVED IN REGULATION (USING DEPHOSPHORYLATIONOF A SPECIFIC PHOSPHORYLATED SUBSTRATE).
Rv0018c, (MTCY10H4.18c), len: 514 aa. Possible ppp,serine/threonine phosphatase (EC 3.1.3.16), equivalent toMLCB1770_13|T10013 PUTATIVE PHOSPHOPROTEIN PHOSPHATASEfrom Mycobacterium leprae (509 aa), FASTA scores: opt:2517, E(): 0. Also highly similar to others e.g. T36714probable protein phosphatase from Streptomyces coelicolor(515 aa); CAA10712.1|AJ132604 pppL protein fromLactococcus lactis (258 aa); NP_248765.1|NC_002516probable phosphoprotein phosphatase from Pseudomonasaeruginosa (242 aa); etc. Also similar to BSUB0009_46 YLOOPROTEIN from Bacillus subtilis (254 aa), FASTA score:(34.0% identity in 250 aa overlap).
experimental evidence, no additional detailsrecorded
External Links: 15607160P71588887070

6
Rv0019c: UNKNOWN
Rv0019c, (MTCY10H4.19c), len: 155 aa. Conservedhypothetical protein, equivalent toMLCB1770_14|NP_301147.1|NC_002677 conserved hypotheticalprotein from Mycobacterium leprae (155 aa), FASTA scores:opt: 902, E(): 0, (91.0% identity in 155 aa overlap). Alsohighly similar to T36713|AL079308|SCH69_14 fromStreptomyces coelicolor (172 aa), FASTA scores: opt: 389,E(): 6e-21, (46.2% identity in 171 aa overlap); andsimilar in C-terminus to others e.g. NP_342559.1|NC_002754Conserved hypothetical protein from Sulfolobussolfataricus (209 aa); etc. C-terminus also highly similarto C-terminal part of AAF07901.1|AF173844_2|AF173844putative signal transduction protein GarA fromMycobacterium smegmatis (158 aa). Also similar toRv1827|MTCY 1A11.16c from Mycobacterium tuberculosis ( 162aa), FASTA score: (41.2% identity in 85 aa overlap);MTMOAIS_3; MAU66560_1 and MLCB1788_15.
experimental evidence, no additional detailsrecorded
External Links: 15607161P71589887079